Lactoperoxidase‐catalyzed lodination of arachidonic acid: Formation of macrolides
- 1 April 1981
- Vol. 16 (4) , 246-249
- https://doi.org/10.1007/bf02535024
Abstract
In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo‐δ‐lactone. Two minor and less polar products have now been characterized as 15‐iodo‐14‐hydroxyeicosatrienoic acid, ω‐lactone and 14‐iodo‐15‐hydroxyeicosatrienoic acid, ω‐lactone, on the basis of125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.Keywords
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