The clinical response of cattle experimentally infected with lumpy skin disease (Neethling) virus

Publisher Website
Google Scholar
Abstract
British cattle were inoculated with lumpy skin disease (Neethling) virus and their clinical signs observed over a three week period. Elevation of body temperature following infection was not found to be a consistent feature, and even in severe cases was limited to a peak temperature of 41 °C. Generalised lesions were seen 9–14 days post infection (p.i.), and the development of generalised infections did not appear to be dose related. Following intradermal inoculation lesions were detected from day 2 p.i. and first appearance and severity of local reaction appeared to be related to dose. Virus isolation was carried out on ocular, nasal and saliva swabs, and on buffy coat preparations. A transient viraemia was detected in two of eleven animals that did not show generalized signs; virus was not isolated from the secretions of seven animals without generalised signs. Virus was isolated from the peripheral secretions of an animal with generalised disease between 9 and 15 days p.i. and viraemia was detected in each of five animals with generalized signs. Delayed-type hypersensitivity reactions following intradermal inoculation of immune cattle with LSDV were found to be maximal at 24 h after challenge.