ISLET CELL-MEMBRANE ALTERATION BY DIABETOGENIC DRUGS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 34  (5) , 451-454
Abstract
Freeze-fracture of [rat] islets of Langerhans treated in vitro with diabetogenic agents alloxan and streptozotocin shows a decrease in the number of intramembranous particles of islet cell plasma membranes. This decrease is restricted to the membrane''s A-fracture face and it can be prevented by experimental conditions which are known to counteract the toxic effect of both alloxan and streptozotocin.