Levels of Plasma Steroid Glucuronides in Intact and Castrated Men with Prostatic Cancer

Publisher Website
Google Scholar
Abstract
The levels of plasma dehydroepiandrosterone (DHEA), androst-5-ene-3β,17β-diol (Δ5-diol), testosterone (T), dihydrostestosterone (DHT), androstane-3α,17β,-diol (3α-diol), androsterone(ADT), and the related glucuronide (G) derivatives were determined in intact and castrated men with prostatic cancer. The plasma concentrations of DHEA and DHEA-G were not significantly differentin intact and castrated men while Δ5-diol as well as Δ5-diol-G were 50% lowered in castrated men. As expected, T and DHT concentrations were markedly lower in castrated men. These low plasma levelsof T and DHT were accompanied by a decrease of 3α-diol, ADT, T-G, 3α-diol-G, and ADT-G levels. There was, in unoperated men, a positive correlation between the levels of DHEA and ADT-G as well as DHEA and DHEA-G, while T values were highly correlated with ADTG and 3α-diol-G levels. Furthermore, a significant relationship was found between DHEA and ADT-G as well as 3α-diol-G in castrated men. Our data clearly demonstrate that ADT-G and 3α-diol-G levels are more affected by castration than are the corresponding unconjugated steroids and suggest that these steroid glucuronides should be good markers of androgen metabolism. Moreover, the significant relationship between DHEA, ADT-G, and 3α-diol-G in castrated men also suggests that approximately 30% of C-19 steroids from the adrenals are converted to T and DHT, which are further transformed into steroid glucuronides.

This publication has 2 references indexed in Scilit: