Postnatal maturation of GABA‐immunoreactive neurons of rat medial prefron tal cortex

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Abstract
A light microscopic immunocytochemical approach has been used to examine the distribution and maturation of γ‐aminobutyric acid‐ (GABA) containing cells in rat medial prefrontal cortex (mPFC) at progressive postnatal stages. Between P1 and P5, labeled cells in the cortical plate show less differentiated morphological characteristics when compared to cells in the deeper laminae. By P10, however, most labeled cells in superficial laminae show more differentiated characteristics with some having a distinctive multipolar appearance. Between P1 and P5, there is a significant increase (50%) in the density of GABA‐containing cells in the superficial laminae, while concurrently there is an overall decrease in the subjacent deeper laminae. As the cortex continues to expand, there is a corresponding decrease in the density of GABA‐immunoreactive cells in the outer two‐thirds of the cortical mantle until approximately P15, stabilizing at 20–25 cells/100,000 μm2 for all laminae. Between P1 and P15, there is also a significant increase (133%) in the average size of labeled cells, followed by a gradual decrease of 30% between P15 and P41. During P1–7, there is a marked increase in the density of labeled axosomatic terminals in both the superficial (200%) and deep laminae (116%). In the superficial layers, however, the density of labeled terminals again increases by 86% between P12 and P18. In general, the present findings are consistent with the idea that there is a progressive maturation of the intrinsic GABAergic system in rat mPFC in a classic “inside‐out” pattern, and this involves extensive postnatal changes occurring during the first 3 postnatal weeks.

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