A New Approach to 5-Substituted Prolines and 2-Pyrrolecarboxylates
- 1 July 1998
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1998 (7) , 731-732
- https://doi.org/10.1055/s-1998-1768
Abstract
Iodocyclisations of the allylic glycinates 7 lead either to the trans- or cis-2,5-disubstituted proline derivatives 8 or 9, depending on the reaction conditions; subsequent treatment of these with DBU in DMF gives the 2-pyrrolecarboxylates 10 and 13 in excellent yields by a double elimination of hydrogen iodide and toluenesulfinic acid.Keywords
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