THE ABSORPTION OF INSULIN FROM THE GASTROINTESTINAL TRACT

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Abstract
Totally depancreatized dogs were able to absorb considerable insulin when given with Ca lactate and NaHCO3. The blood sugar usually fell 40-90 mgm.% and the urine usually became sugar free for 4-8 hrs. after administration. The Ca lactate and NaHC03 are believed to act as buffers removing the free HC1 from the stomach and protecting the insulin from destruction by pepsin. When blood serum was added to the mixture, absorption was increased as shown by the greater fall in blood sugar and a greater rise in the respiratory quotient.

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