Functional Correlates of Serotonin 5-HT1Recognition Sites
- 1 January 1988
- journal article
- review article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 8 (1-4) , 59-81
- https://doi.org/10.3109/10799898809048978
Abstract
A short overview is given of the evidence supporting the existence of subtypes of 5-HT1 receptors. As 5-HT1 receptors were first described using radioligand binding studies, a brief description of 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptor binding is given. Then, recent data obtained in biochemical, electrophysiological, behavioural and other functional studies is compared to results obtained in radioligand binding studies. The paper shows that functional correlates do indeed exist for subtypes of 5-HT1 recognition sites; moreover, these are markedly different from the effects mediated by 5-HT2 (5-HT D) or 5-HT3 (5-HT M) receptors.Keywords
This publication has 59 references indexed in Scilit:
- Agonist‐Induced Phosphoinositide Hydrolysis in Choroid PlexusJournal of Neurochemistry, 1986
- A G Protein Couples Serotonin and GABA B Receptors to the Same Channels in HippocampusScience, 1986
- In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminalsJournal of Neuroscience, 1986
- Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamineNeuropharmacology, 1986
- A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover.Proceedings of the National Academy of Sciences, 1986
- Identification of Multiple Binding Sites for [3H]5‐Hydroxytryptamine in the Rat CNSJournal of Neurochemistry, 1986
- 5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized catsBritish Journal of Pharmacology, 1986
- An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidneyNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1986
- Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1BLife Sciences, 1986
- Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonistsEuropean Journal of Pharmacology, 1985