Asymmetric hydrogenation of prochiral alkenes catalysed by ruthenium complexes of (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1571-1575
- https://doi.org/10.1039/p19890001571
Abstract
Two chiral ruthenium(II) complexes containing (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl[(R)-BINAP] were found to be effective catalysts for the asymmetric hydrogenation of 2-acylaminoacrylic and 2-acylaminocinnamic acids under mild conditions, to afford N-acyl-(R)-α-amino acids with 49–95% optical purity. The differences between the asymmetric hydrogenations effected by RuII- and RhI-(R)-BINAP systems are discussed. Asymmetric hydrogenation of methylenesuccinic acid and its derivatives with Ru-(R)-BINAP is also described.Keywords
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