The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase
Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (17) , 8973-8976
- https://doi.org/10.1128/jvi.76.17.8973-8976.2002
Abstract
Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.Keywords
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