A Practical Synthesis of the ABC Ring Model of Ecteinascidins.
- 1 January 2000
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 48 (10) , 1549-1557
- https://doi.org/10.1248/cpb.48.1549
Abstract
A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3- benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%.Keywords
This publication has 0 references indexed in Scilit: