A Hyaluronidase Supercatalyst for the Enzymatic Polymerization to Synthesize Glycosaminoglycans
- 26 July 2006
- journal article
- concept
- Published by Wiley in Chemistry – A European Journal
- Vol. 12 (23) , 5962-5971
- https://doi.org/10.1002/chem.200600191
Abstract
Hyaluronidase (HAase) catalyzes multiple enzymatic polymerizations with controlling regio- and stereoselectivity perfectly. This behavior, that is, the single enzyme being effective for multireactions and retaining the enzyme catalytic specificity, is not usual, and hence, HAase is a supercatalyst. Various sugar oxazoline monomers prepared based on the concept “transition-state analogue substrate” were successfully polymerized and copolymerized with HAase catalysis, yielding natural and unnatural glycosaminoglycans.Keywords
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