Release of T‐kinin and bradykinin in carrageenin induced inflammation in the rat
- 14 October 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 190 (2) , 268-270
- https://doi.org/10.1016/0014-5793(85)81297-7
Abstract
Plasma and inflammatory fluid kininogen levels, and blood and inflammatory fluid free kinin levels were determined in rats 24 h after the injection of carrageenin into an air pouch. Plasma T-kininogen levels increased 7-fold. In the inflammatory fluid levels reached 8 μgml. Blood levels of free kinin showed a 5-fold increase. The kinins were identified on HPLC as T-kinin (Ile-Ser-bradykinin) and bradykinin, 63 and 37%, respectively. These results indicate for the first time that free T-kinin as well as bradykinin is released during an inflammatory response in rat and confirms our previous finding that T-kininogen may be a major acutephase protein in inflammation.T-kininT-kininogenBradykininInflammationAcute-phase proteinCarrageeniKeywords
This publication has 8 references indexed in Scilit:
- T-kininogen - the major plasma kininogen in rat adjuvant arthritisBiochemical and Biophysical Research Communications, 1985
- Major acute phase α1‐protein of the rat is homologous to bovine kininogen and contains the sequence for bradykinin: its synthesis is regulated at the mRNA levelFEBS Letters, 1985
- Detection and quantitation of fluorescamine-labeled bradykinin, its analogues and metabolites using high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1984
- Pharmacological properties of T-kinin (isoleucyl-seryl-bradykinin) from rat plasmaBiochemical Pharmacology, 1983
- Isolation and structure of T-kininBiochemical and Biophysical Research Communications, 1983
- Kininogen substrates for trypsin and cathepsin D in human, rabbit and rat plasmasLife Sciences, 1983
- Aspects of bradykinin radioimmunoassayJournal of Immunological Methods, 1978
- The effect of locally injected anti-inflammatory drugs on the synthesis of collagen and non-collagen protein of carrageenin granuloma in ratsBiochemical Pharmacology, 1969