Og4C3 Circulating Antigen: A Marker of Infection and Adult Worm Burden in Wuchereria bancrofti Filariasis
- 1 July 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 170 (1) , 247-250
- https://doi.org/10.1093/infdis/170.1.247
Abstract
Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.Keywords
This publication has 0 references indexed in Scilit: