Selenite suppresses hydrogen peroxide‐induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3‐K/Akt pathways
Open Access
- 14 November 2001
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 16 (1) , 1-27
- https://doi.org/10.1096/fj.01-0398fje
Abstract
The relationship between selenium and signal molecules has not been well elucidated. It was found that physiological concentration of selenite, >3 μM, reduced ASK1 activity and induced PI3-kinase (PI...Keywords
Funding Information
- Molecular Medicine Research Center, Hormozgan University of Medical Sciences (M1-0106-00-0076)
This publication has 42 references indexed in Scilit:
- Pro‐apoptotic function of calsenilin/DREAM/KChIP3The FASEB Journal, 2001
- Extracellular Zinc Activates p70 S6 Kinase through the Phosphatidylinositol 3-Kinase Signaling PathwayJournal of Biological Chemistry, 2000
- Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death PathwayScience, 2000
- Caspases: Enemies WithinScience, 1998
- Mitochondria and ApoptosisScience, 1998
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling PathwaysScience, 1997
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience, 1996
- Metabolic effect of sodium selenite: Insulin-like inhibition of glucagon-stimulated glycogenolysis in the isolated perfused rat liverHepatology, 1995
- Apoptosis in the Pathogenesis and Treatment of DiseaseScience, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995