The orbitotemporal cortex of 11 patients undergoing pituitary surgery for the palliation of metastatic cancer was studied for autonomic responses to electrical stimulation. General anesthesia was used, and recordings were made of blood pressure, pulse rate, respiration, esophageal and gastric motility, and,the pneumoplethysmo-gram. Responses from the posterior orbital region and the infundibulum of the hypothalamus were meager, although mechanical stimulation coincident with section of the hypophyseal stalk might yield profound changes. An area on the anterior uncus at its junction with the hippocampal gyrus produced well-defined constant responses. The blood pressure usually fell coincident with bradycardia but might rise. Respiration was inhibited or arrested. Arrest might occur at any stage in the respiratory cycle. Esophageal contractions appeared which might follow or be independent of the laryngeal component of deglutination. In two instances, a well-defined increase in gastric contractions occurred. No changes were noted in the plethysmogram. The similarity of this complex of responses to that elicited by afferent stimulation of the superior laryngeal nerves and vagi in lower animals was noted and discussed.