The Problem of the Coronary Changes Due To Disturbance of Vascular Wall Permeability

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Abstract
In the muscular small vessels of the heart a new type of the patho-mechanism of vascular changes has been described. The essence of the change is a disturbance of vascular wall transport. Twenty-four dogs of both sexes, divided into 2 groups, were used. In the first group the animals were treated with norepinephrine and dihydroper-parin. In the animals of the second group the pericardiac lymph nodes, lymphatics, and thoracic duct were ligated. On the basis of our observations the characteristic morphologic features of these vascular changes may be summed up as follows. In their development the plasma imbition plays the primary, decisive role. Initially, they occur between endothelium and internal elastic membrane/lamina elastica interna. In the course of their persistence, characteristic changes take place in their staining, presumably depending on the participation of plasma fractions of lower or higher molecular weight preponderant in their formation. Later, plasma is accumulated in the media, too, whence, if not joined by necroses of the smooth muscle cells, it may be absorbed by way of the lymphatics. In the opposite case fibrinoid necroses of the vascular wall develops.