Tumor necrosis factor α (TNFα) induces pro‐matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1 α antagonizes the inductive effect of TNFα
Open Access
- 30 November 1999
- journal article
- Published by Wiley
- Vol. 392 (2) , 175-178
- https://doi.org/10.1016/0014-5793(96)00808-3
Abstract
We have examined the regulation of precursor of matrix metalloproteinase 9 (proMMP‐9)/progelatinase B production by tumor necrosis factor α (TNFα) and interleukin 1α (IL‐1α) using human uterine cervical fibroblasts. TNFα, but not IL‐1α, induces the production of proMMP‐9 in the cervical cells. IL‐1α, however, suppresses the TNFα‐induced proMMP‐9 production. 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) also stimulates the cervical cells to produce proMMP‐9, and IL‐1α synergistically enhances its production. TNFα‐induced proMMP‐9 production is not mediated by protein kinase C (PKC), whereas the effect of IL‐1α is through PKC. By contrast, proMMP‐3/prostromelysin 1 is up‐regulated by TNFα or TPA in the presence of IL‐1α, whose modulation is PKC‐dependent. The suppressive effect of IL‐1α on the TNFα‐induced proMMP‐9 production is a new biological effect of IL‐1 on MMP production.Keywords
This publication has 26 references indexed in Scilit:
- Tumor Cell Interactions with the Extracellular Matrix During Invasion and MetastasisAnnual Review of Cell Biology, 1993
- Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavityInternational Journal of Cancer, 1993
- Induction of metalloproteinase activity in human T-lymphocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1993
- Differential regulation of gelatinase b and tissue‐type plasminogen activator expression in human bowes melanoma cellsInternational Journal of Cancer, 1993
- Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines.Journal of Clinical Investigation, 1991
- NF-κB activation by tumor necrosis factor α in the jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca2+-regulated kinasesCytokine, 1991
- THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONSAnnual Review of Biochemistry, 1989
- Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblastsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase CBiochemistry, 1984
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970