OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES
- 1 January 2002
- journal article
- Published by Taylor & Francis in Journal of Liposome Research
- Vol. 12 (1-2) , 95-106
- https://doi.org/10.1081/lpr-120004781
Abstract
The rationale design aimed at the enhancement of cationic lipid mediated gene transfer is discussed. These improvements are based on the straight evaluation of the structure-activity relationship and on the introduction of new structures. Much attention have been given to the supramolecular structures of the lipid/DNA complexes, to the effect of serum on gene transfer and to the intracellular trafficking of the lipoplexes. Finally new avenue using reducible cationic lipids has been discussed.Keywords
This publication has 18 references indexed in Scilit:
- Reducible cationic lipids for gene transferBiochemical Journal, 2001
- Nonviral Vectors in the New Millennium: Delivery Barriers in Gene TransferHuman Gene Therapy, 2001
- Synthesis of New Cationic Lipids from an Unsaturated Glycoside ScaffoldOrganic Letters, 2001
- Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transferThe Journal of Gene Medicine, 2001
- Synthesis and transfecting properties of a glycosylated polycationic DNA vector 1Bioorganic & Medicinal Chemistry Letters, 2001
- Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene ExpressionJournal of Medicinal Chemistry, 2000
- Synthesis and biological properties of new glycosidic cationic lipids for DNA deliveryBioorganic & Medicinal Chemistry Letters, 2000
- Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systemsBioorganic & Medicinal Chemistry Letters, 2000
- Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiencyNucleic Acids Research, 1999
- Introduction of a Disulfide Bond into a Cationic Lipid Enhances Transgene Expression of Plasmid DNABiochemical and Biophysical Research Communications, 1998