RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms
Open Access
- 23 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 300 (1) , 97-100
- https://doi.org/10.1016/0014-5793(92)80172-d
Abstract
A method for the rapid preparation of a defined substrate to monitor RNase H activity has been developed. Using this substrate, we have investigated the RNase H activities of the different forms of recombinant HIV‐1 and HIV‐2 reverse, transcriptase (RT) in detail. As we report here, RNase H activity is associated only with the dimeric forms (p51/p66 or p66/p66) of the enzymesKeywords
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