Experimental Inclusion Conjunctivitis in Man

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Abstract
Volunteers infected with inclusion conjunctivitis agent regularly developed keratitis in addition to acute follicular conjunctivitis. The corneal signs included epithelial keratitis, marginal and central subepithelial infiltrates, and focal neovascularization at the limbus. In reinfected volunteers, keratitis was no more frequent but appeared sooner than in initial infections. In three instances, anterior uveitis appeared during the course of experimental infections. In two volunteers this occurred in conjunction with the reactivations of conjunctival disease. Although there is considerable overlapping of the clinical signs of classic trachoma and inclusion conjunctivitis in adults, the two diseases should still be regarded as distinct clinical entities.

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