THE ROLE OF THE THYROID IN THE PRODUCTION OF CARDIOVASCULAR AND RENAL CHANGES BY METHYLANDROSTENEDIOL

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Abstract
SUMMARY Earlier experiments have shown that treatment with methylandrostenediol (MAD) results in the accumulation of hyalin granules in the adrenocortical cells. This is accompanied by the development of nephrosclerosis, periarteritis nodosa, myocarditis and other changes characteristic of an intoxication with mineralo-corticoids such as desoxycorticosterone. It had also been found that adrenalectomy prevents all these effects of MAD. The present experiments on rats show that, in the absence of the thyroid, the production by this steroid of hyalin granules in the adrenals is diminished but not abolished. At the same time there occurs a dissociation in the other actions of MAD in so far as nephrosclerosis, myocarditis and hypertension are largely inhibited; polyuria, thymus involution and the effects typical of all androgens are uninfluenced; while the severity of mesenteric periarteritis nodosa is actually aggravated by thyroidectomy. The significance of this dissociation is discussed in relation to the effects produced by excessive amounts of androgenic or mineralo-corticoid compounds.

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