DNA Building Block Reinvented
- 5 July 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5578) , 61-62
- https://doi.org/10.1126/science.1073910
Abstract
It might be assumed that mechanisms for the biosynthesis of essential DNA precursors would be conserved in all organisms. However, Murzin discusses new work ( Myllykallio et al.) showing that a large family of enzymes, named ThyX, synthesize thymidylate by an alternate mechanism. The structure of ThyX has been determined independently and together these findings pave the way for rational drug design.Keywords
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