Excitation parameters of the repetitive firing mechanism from a statistical evaluation of nerve impulse trains

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Abstract
Repetitive firing of single tonic neurones is modeled to include in detail both membrane excitation kinetics and electrotonic effects due to membrane non-uniformities in the impulse encoder region. The model is evaluated dynamically and compared with similar data obtained from the crayfish stretch receptor neuron. Two dynamic techniques utilizing small amplitude sinusoidal signals are employed. One technique is used to fix the values of two parameters which relate to the electrotonic control of membrane potential in the interspike interval and to the relaxation time of the K-conductance during repetitive firing. The other technique is employed as a consistency check. The dynamics are particularly sensitive to the K-channel relaxation time in the interspike interval.