EFFECT OF THE PITUITARY INHIBITOR I.C.I. 33,828 (METHALLIBURE) ON THE REPRODUCTIVE SYSTEM OF MALE RATS

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Abstract
SUMMARY: Impairment of pituitary function in male rats by I.C.I. 33,828 (1-α-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine; methallibure) caused arrest of sperm iogenesis beyond step 8, without apparently interfering with the timing of the cycle of the seminiferous epithelium. In this respect there was a close similarity between the effect of the drug and that of hypophysectomy. Uninterrupted daily administration was required and after cessation of treatment, pituitary function was rapidly restored. The antifertility effect of the compound in male rats is due to reduced libido, arrest of spermiogenesis and possibly the induction of 'lethal mutations' in developing germ cells.