Fine Needle Aspiration Biopsy vs. Ultrasound-Guided Transrectal Random Core Biopsy of the Prostate

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Abstract
To compare fine needle aspiration biopsy (FNAB) and ultrasound-guided transrectal core biopsy of the prostate. FNAB and the random core biopsy were performed simultaneously on 246 patients who either had striking palpable signs or increased levels of prostate-specific antigen, at least 5 micrograms/mL, on two separate examinations over a six-week period, The histologic and cytologic evaluations showed very close conformity between the two methods. Fifty-eight percent of the patients had benign prostate hyperplasia. Of the total number of patients, 103 (42%) had prostate carcinoma. This figure was confirmed in 101 (98%) of cases using FNAB. In two cases (0.8%) atypical prostate hyperplasia was diagnosed. In five cases the examination had to be repeated since insufficient prostate cell material was collected. Ultrasound-guided random core biopsy showed the presence of carcinoma in 96 of 103 patients (93%). It was necessary to repeat the examination in one patient due to a lack of adequate cell material. In our hands, FNAB method has a sensitivity of 98%, whereas core biopsy attained 91%. Both methods showed 100% concurrence in specificity.

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