Transgenic mouse model for the fragile X syndrome
- 9 August 1996
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 64 (2) , 241-245
- https://doi.org/10.1002/(sici)1096-8628(19960809)64:2<241::aid-ajmg1>3.0.co;2-x
Abstract
Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome.Keywords
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