Metabolites of quinoline, a hepatocarcinogen, in a subcellular microsomal system.

Publisher Website
Google Scholar
Abstract
It was evidenced that quinoline was metabolized to quinoline 1-oxide catalyzed by cytochrome P-450-linked mixed function monooxygenase system and to 5, 6-trans-dihydroxy-5, 6-dihydroquinoline by cytochrome P-448-linked one. The third metabolite, 3-hydroxyquinoline, may be produced in another course of metabolism, which might be connected with genotoxicity of quinoline, as previously discussed.

This publication has 0 references indexed in Scilit: