Suppression of an AKR Lymphoma by Antibody and Chlorambucil2
- 1 December 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 55 (6) , 1353-1357
- https://doi.org/10.1093/jnci/55.6.1353
Abstract
A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody. Exposure of the lymphoma cells to chlorambucil-bound antibody caused greater tumor inhibition both in vitro and in vivo than did the synergistic effect of exposure separately to the antibody and chlorambucil.Keywords
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