GLOBULIN FRACTIONS OF A AND B AGGLUTINATING SERUMS FOR BLOOD TYPING

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Abstract
It is well known that it is difficult to secure large amounts of high titered A and B serums for determining blood groups. It is especially difficult to secure satisfactory A serum. Since it has been demonstrated that antibodies can be concentrated by various methods of globulin fractionation, globulin fractions were prepared of pooled type A and pooled type B serums in the attempt to concentrate these specific isoagglutinins. It was felt that if this could be accomplished it would not be necessary to secure high titered agglutinating serums from the small percentage of individuals who yield these, but the agglutinins could be concentrated sufficiently in the globulin fraction from pools of low titered serums. It has been found, as the study progressed during, the past two years, that it was extremely easy to accomplish this. One or two liter pools were prepared, and the agglutinin titer of each individual

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