Liver biopsies upsilon liver scans in methotrexate-treated patients with psoriasis

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Abstract
The possibility of hepatotoxic reactions in 24 patients receiving long-term methotrexate therapy for psoriasis was evaluated by both liver biopsies and 99mTc sulfur-colloid liver scans. The 2 diagnostic methods were compared in a retrospective analysis. Of 17 patients with clinically normal liver biopsy interpretations, had abnormal liver scans, while 3 of 5 patients with histologically proved fibrosis, had completely normal liver scans. Hepatotoxic reactions from long-term methotrexate use in psoriasis cannot be reliably evaluated by the 99mTc sulfur colloid liver scan.

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