Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis

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Abstract
Thyroid function and serum TSI levels in two siblings with neonatal thyrotoxicosis are described. The first infant was treated with exchange transfusion and potassium iodide. The second infant was treated with intrauterine propylthiouracil followed by potassium iodide. In contrast to the first infant, the second infant had no clinical sign of neonatal thyrotoxicosis. He also had lower TSI levels with a biological halflife of 5 days. Only one of three assays showed some TSI activity in breast milk.