Synthesis of 6,7-bis(trifluoromethyl)-8-substituted pteridine-2,4(1H,3H)-dione (lumazine) hydrates from 4,5-diaminouracil hydrochlorides and perfluorobutane-2,3-dione. Stabilization of the transmolecular covalent hydrates of 8-substituted pteridinediones by trifluoromethyl groups
- 31 December 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 1051-1053
- https://doi.org/10.1039/p19860001051
Abstract
The reaction of perfluorobutane-2,3-dione (PFBD) with substituted 4,5-diaminouracil hydrochlorides (15) and (16) has been investigated in an attempt to determine the extent to which trifluoromethyl groups placed in the 6 and 7 positions of the 8-substituted lumazine products stabilize the transmolecular covalent hydrate forms. The compounds prepared in this manner were found to exist as stable hydrates (17) and (18).This publication has 1 reference indexed in Scilit:
- Synthesis of bis(trifluoromethylated) pyrazine-containing nitrogen heterocycles from hexafluorobiacetyl and ortho-diamines. Stabilization of the covalent dihydrates of pteridines and pyrido[3,4-b]pyrazines by trifluoromethyl groupsJournal of the Chemical Society, Perkin Transactions 1, 1986