Effects of Benfluorex on Insulin Resistance and Lipid Metabolism in Obese Type II Diabetic Patients
- 1 April 1993
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 16 (4) , 557-559
- https://doi.org/10.2337/diacare.16.4.557
Abstract
OBJECTIVE To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk. RESEARCH DESIGN AND METHODS The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg−1 · h−1 (clamp 2). RESULTS Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg−1.min−1 after benfluorex and placebo, respectively (P = 0.018). CONCLUSIONS Benfluorex increases insulin sensitivity in obese type II diabetic patients.Keywords
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