Dilute Hydrofluoric Acid as a Fluorinating Agent: Iodofluorination of Olefins with Dilute Hydrofluoric Acid,N-Iodosuccinimide, and a Phase Transfer Catalyst
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (03) , 185-186
- https://doi.org/10.1055/s-1991-20672
Abstract
Regio-, stereo-, and chemoselective iodofluorination of olefins is readily effected under a two-phase system using dilute hydrofluoric acid, N-iodosuccinimide, and tetrabutylammonium fluoride as a phase transfer catalyst. Additional use of potassium hydrogen fluoride (KHF2) enhanced the yields of fluoro-iodo adducts and suppressed the formation of iodohydrins as byproducts.Keywords
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