SPECIFICITY OF ADHESION BETWEEN MURINE TUMOR-CELLS AND CAPILLARY ENDOTHELIUM - AN INVITRO CORRELATE OF PREFERENTIAL METASTASIS INVIVO
- 15 March 1987
- journal article
- research article
- Vol. 47 (6) , 1492-1496
Abstract
We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayers have included murine microvascular endothelial cells from ovary, brain, lung, and liver as well as large vessel endothelium from thoracic duct and dorsal aorta. Tumor cells differ both in the adhesive propensity and adhesive preference for different endothelial cells. Some, but not all, of the adhesive preferences correlate with the known in vivo metastatic behavior of these tumors. Our results support the hypothesis that endothelial cell surface-associated specificities may play a significant role in determining the pattern of metastasis.This publication has 13 references indexed in Scilit:
- Differential adhesion of tumor cells to capillary endothelial cells in vitro.Proceedings of the National Academy of Sciences, 1984
- Invasive behavior of mouse sarcoma cells is inhibited by blocking a 37,000-dalton plasma membrane glycoprotein with Fab fragments.Proceedings of the National Academy of Sciences, 1984
- Male murine embryonal carcinoma cell line selectively metastatic to the ovaries and adrenalsVirchows Archiv B Cell Pathology Including Molecular Pathology, 1983
- Monoclonal antibodies that prevent adhesion of B 16 melanoma cells and reduce metastases in mice: crossreaction with human tumor cells.Proceedings of the National Academy of Sciences, 1983
- Embryonal carcinoma cell adhesion: The role of surface galactosyltransferase and its 90K lactosaminoglycan substrateDevelopmental Biology, 1983
- Monoclonal antibody against angiotensin-converting enzyme: its use as a marker for murine, bovine, and human endothelial cells.Proceedings of the National Academy of Sciences, 1982
- Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers.Journal of Histochemistry & Cytochemistry, 1982
- Ovarian localization by embryonal teratocarcinoma cells derived from female germ gellsSomatic Cell and Molecular Genetics, 1979
- Analysis of cell recombinations in experimental synthesis of tissuesin vitroJournal of Cellular and Comparative Physiology, 1962
- Experiments of the fate of embryonic cells (chick) disseminated by the vascular routeJournal of Experimental Zoology, 1952