The Experimental Production of Extraskeletal Bone-Forming Neoplasms in the Rat

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Abstract
Among 7,500 neoplasms induced in the rat''s liver by Cysticercus jascicolaris, 49 were bone forming tumors. 6 of these have been previously reported (Jour. Cancer Research 9, 425, 1925, 12, 326, 1928). These rare bone-forming tumors were fortuitously distributed in the several lobes of the liver, in 5 different inbred strains of rats, and varied, like the none-boneforming neoplasms of the series from benign to highly malignant growths. The hosts had from 1-64 parasitic cysts and the latent period was extremely variable. 66 bone forming neoplasms were observed in a series of 2351 tumors induced in rats by the subcutaneous injn. of paraffin containing 34 benzpyrene. These neoplasms occurred in rats of both sexes of 7 different inbred strains. The bone-forming neoplasms were induced by 3 concs. of benzpyrene, namely 1.0, 0.25 and 0.10% and comprised 1%, 7% and 20% of the tumors induced by these respective concs. of the incitant. The conc. of the incitant affected the rate of growth and malignancy of the induced neoplasms. Tumors induced by 1% benzpyrene had a shorter latent period, a greater avg. daily increase in diam., and killed the host in a shorter avg. interval after observation than tumors which were induced by weaker cones. of benzpyrene. The bone-forming neoplasms induced by 1% benzpyrene had a longer avg. latent period, longer avg. period from observation to death and a smaller avg. daily increase in diam. than the avg. of the series. The most favorable incitant of the heteroplastic bone-forming neoplasms was 0.10% benzpyrene in paraffin.

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