5,6,7,8-Tetrahydroquinolines. 5. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinethioureas and related heterocycles
- 1 May 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (5) , 718-721
- https://doi.org/10.1021/jm00215a020
Abstract
A series of thioureas derived from 5,6,7,8-tetrahydroquinoline, 1,5-, 1,6- and 1,8-naphthyridines, pyrido[2,3-b]azepine, and 7-azaindoline was prepared and tested for antisecretory activity in the pylorus-ligated rat and protective activity against gastric erosions caused by cold-restraint stress. The thioureas exhibited different structure-activity relationships from the corresponding 5,6,7,8-tetrahydroquinoline-8-thiocarboxamides and these relationships are discussed. The activity of the thioureas is less affected by structural differences than the corresponding thioamides although they probably have the same mode of action.This publication has 1 reference indexed in Scilit:
- 5,6,7,8-Tetrahydroquinolines. 4. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinenitriles and -thioamidesJournal of Medicinal Chemistry, 1977