Components of the rat conceptus that account for prolactin inhibition

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Abstract
The secretions from developed concepti in the rat appear to inhibit both the rhythmic nocturnal secretion of prolactin (Prl) during the 2nd half of pregnancy and the neurally mediated Prl release in response to suckling stimulation. To identify the parts of the concepti capable of inhibiting Prl secretion, the components of the concepti were systemically removed and their effect on plasma Prl levels was examined. In the 1st experiment, feamle rats which were simultaneously pregnant and lactating were tested for Prl secretion in response to suckling stimulation after one of the following treatments; removal of the fetuses only, removal of the fetuses and trophoblasts, removal of the complete concepti. In the 2nd experiment, pregnant rats were tested for the presence of nocturnal Prl surges after either removal of the fetuses and trophoblasts or removal of the entire concepti. Apparently, after removal of the fetuses alone, the inhibition of Prl secretion remains. Following removal of both the fetus and the trophoblast, leaving the decidua in situ with a supplementary progesterone implant, the decidua still retain a partial capacity to inhibit Prl secretion in response to suckling stimulation, while their inhibitory effect on nocturnal Prl surges was very minute. Degeneration of the decidua occurred following the removal of the trophoblast, when no exogenous progesterone was supplied. The deterioration of the decidua or total removal of the concepti eliminates the entire inhibition of Prl secretion, both on the nocturnal surges as well as in response to suckling stimulation. Evidently, after mid-pregnancy the trophoblast cell secretes a substance that both inhibits Prl secretion and maintains the corpus luteum; the decidua at the same time secretes a substance that has a partial capacity to inhibit Prl secretion in response to suckling stimulation.