Histopathology of Guinea Pigs with Cholesterol-Induced Anemia.

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Abstract
Guinea pigs respond to dietary cholesterol with the development of hemolytic anemia accompanied by striking pathological changes of most organs. Liver, spleen, lung and the zona fasciculata of the adrenals showed fatty infiltration and accumulation of hemosiderin and cholesterol. Extramedullar erythropoietic proliferation was seen in liver, spleen and kidney. Testes were small and spermatogenesis was greatly impaired. The bone marrow was hyperplastic and kidneys showed glomerulosclerosis. The pancreas and heart were unaffected. The changes observed resulted primarily from alterations in the cellular structure caused by the accumulation of cholesterol, and secondarily from impaired liver function and the effects of the hemolytic process.