Increased synthesis of poly(ADP‐ribose) in isolated liver nuclei from autoimmune NZB/NZW mice
- 11 May 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 215 (2) , 252-256
- https://doi.org/10.1016/0014-5793(87)80156-4
Abstract
The synthesis and degradation of poly(ADP-ribose) were investigated in isolated liver nuclei from autoimmune NZB/W mice and four strains of normal mice. Compared to normal mice the maximum levels of incorporation of P[3H]NAD into poly(ADP-ribose) were increased about 2-fold in the autoimmune mice. The kinetics of incorporation suggested that this change was due to an increase in the activity of the polymerase rather than a decrease in the level of degradative enzymes. Thus there may be a connection between autoimmunity and poly(ADP-ribose) metabolism.Keywords
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