Highly regioselective synthesis of 1,7-diprotected 1,4,7,10-tetraazacyclododecane derivatives
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1317-1318
- https://doi.org/10.1039/c39910001317
Abstract
Reaction of dimethylformamicle diethyl acetal with monoalkylated 1,4,7,10-tetraazacyclododecane derivatives 3, followed by hydrolysis of the tricyclic intermediates 4, selectively affords 1,7-disubstituted tetraazamacrocycles 5.Keywords
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