INFLUENCE OF BETA-ADRENERGIC ANTAGONISM ON THE RESPONSE OF BOVINE NEONATAL LUNGS TO INTRAVENOUS HISTAMINE
- 1 January 1982
- journal article
- research article
- Vol. 43 (6) , 984-988
Abstract
The effects of i.v. histamine infusion and .beta.-adrenergic blockade on pulmonary function were studied in neonatal Holstein calves. .beta.-Adrenergic blockade with i.v. propranolol increased total pulmonary resistance but was without effect on lung compliance, lung volumes and gas exchange. .beta.-Adrenergic blockade enhanced the histamine-induced increase in total pulmonary resistance and the decrease in dynamic and quasistatic compliance, lung volumes and arterial O2 tension. .beta.-Adrenergic receptors may be present in the large and small airways of cattle and modulate the effects of bronchoconstrictor agents as in other species.This publication has 3 references indexed in Scilit:
- Histamine H1, H2 Receptor Effects on Mechanics of Ventilation and Gas Exchange in Neonatal CalvesAmerican Journal of Veterinary Research, 1981
- Adrenergic influences on histamine-mediated bronchoconstriction in the guinea pigJournal of Applied Physiology, 1978
- beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agentsJournal of Applied Physiology, 1977