Histopathological Studies on Autopsied Cases of Stomach Cancer Treated with Anticancerous Drugs

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Abstract
20 specimens sampled at autopsy of stomach cancer cases treated with anticancerous drugs were histopathologically studied, with similar specimens from 27 cases not treated with such drugs as controls. In the drug-treated cases, atrophy, dissolution, necrosis and such non-specific retrogressive degeneration of cancer cells were quantitatively more advanced than in the control specimens. Such changes were particularly observable in the tip of cancerous proliferation, and more notable in scirrhous cancer than in medullary carcinoma or carcinoma simplex. As more mild changes attributable to the effect of anticancerous drugs, disparity in size and form, atypical mitosis, mucous degeneration, giant cell formation and squamous cell metaplasia were more frequently found. These changes were similar in the controls. After administration of alkylating substances and Azan, the stroma was highly edematous, the cell reaction was mild, and the degeneration and dissolution of contiguous cancerous tissue was notable. After antibiotics administration the stromatic reaction remained rather well preserved, but coagulative necrosis and variegation of the cancer tissue in original form were advanced. After intra-peritoneal application of isotopic gold, characteristic findings were observed in the granulation foci of non-specific peritonitis. In the drug-treated cases, the liver showed the changes of edema, cell swelling and small necrotic foci, and the adrenal glands revealed swelling of the cortex and in most cases after Nitromin derivatives administration the acute excitation lesions of swelling and dissolution of adrenocortical cells; after administration of antibiotics such lesions were milder and the cytoplasm was found amplified. In the cases pretreated with ACTH, such lesions were always kept mild, swelling of the cortical cells alone being marked. Findings of embolic necrosis and thrombi probably secondary to vascular lesions were notable in some cases after Azan and alkylating agents.

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