Endotoxin-Induced Wasting Disease in Mice: A Temporary Condition Explained by Endotoxin Tolerance.

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Abstract
Summary 1. Bacterial endotoxin causes a loss of thymic lymphocytes and a change in thymic morphology regardless of the age or stage of development of the mouse. 2. Injection of endotoxin into neonatal mice every 3 days causes a temporarily stunted growth rate, as manifested by slower gain in total body weight than that seen in saline injected controls. 3. That the was ting-like syndrome induced by endotoxin is temporary appears to be due to the development of tolerance to the effect of endotoxin on the thymus.