Decrease in survival time in β2‐adrenoceptor blocked cats exposed to bleeding
- 1 October 1984
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 122 (2) , 181-186
- https://doi.org/10.1111/j.1748-1716.1984.tb07496.x
Abstract
Previous investigations have indicated that .beta.2-adrenergic regulatory mechanisms contribute to important compensatory hemodynamic adjustments in hemorrhage. This study examined by comparative observations after standardized fatal hemorrhage on cats with intact and ''selectively'' blocked .beta.2-adrenoceptor (ICI 118.551), whether such compensatory effects are crucial for survival. On the average, the survival time after bleeding was 686 min in cats with intact and 427 min in cats with blocked .beta.2-adrenoceptors (P < 0.05), the difference thus approaching 4.5 h. Reduced survival time after .beta.2-blockade, at least partly, can be ascribed to interference with the circulatory .beta.2-adrenergic control in hemorrhage aimed at improving tissue perfusion.Keywords
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