Reduction of Zearalenone to Zearalenol in Female Rat Liver by 3α‐Hydroxysteroid Dehydrogenase
- 1 February 1981
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 48 (2) , 157-161
- https://doi.org/10.1111/j.1600-0773.1981.tb01602.x
Abstract
The distribution of the zearalenone reducing activity was investigated in liver fractions obtained by differential centrifugation of liver homogenate from adult female Sprague Dawley rats. The zearalenone reducing enzyme was identified as 3α‐hydroxysteroid dehydrogenase. At least two multiple forms occur of the enzyme with different subcellular locations and pH‐optima. The activity was localized in the microsomes with NADH as coenzyme and in both microsomes and cytosol with NADPH.Keywords
This publication has 10 references indexed in Scilit:
- Metabolism of Zearalenone in Rat LiverActa Pharmacologica et Toxicologica, 1978
- BINDING CHARACTERISTICS OF ZEARALENONE ANALOGS TO ESTROGEN RECEPTORS1978
- Chemistry of Zearalenone and Some of Its DerivativesHETEROCYCLES, 1975
- UV-Assay with Pyruvate and NADHPublished by Elsevier ,1974
- The subcellular distribution and properties of aldehyde dehydrogenases in rat liverBiochemical Journal, 1973
- Sexuell differenzierte und sexuell undifferenzierte 3α- und 3β-Hydroxysteroid-Dehydrogenase-Aktivitäten und ihre intrazelluläre Lokalisation in der RattenleberHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1973
- Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic StudiesJournal of Biological Chemistry, 1962
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951