The fate of experimental occlusive venous thrombi a combined histological and venographic study

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Abstract
Although recanalization of occluded veins is thought to be a common occurrence, careful repeated venographic follow-up of patients suggests that this is rare. An experimental study of the fate of occlusive venous thrombi was carried out by matching the function of the occluded veins over varying intervals of time up to 12 weeks with their histological appearance. The results show that although large endotheliallined spaces regularly occur in occluded veins, they seldom interconnect to allow a continuous functional channel. In this experiment, therefore, there was little evidence of functional recanalization. The difficulties of the interpretation of both histological and venographic examinations are discussed and it is suggested that where possible a combination of both methods of investigation would provide the most accurate information on the fate of occlusive venous thrombosis.