Autoimmunity in Relation to Aging as Measured by Agar Plaque Technique.

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Abstract
Summary A substantial proportion (47%) of apparently healthy old mice possessed significantly greater numbers of spleen cells capable of autoimmune hemolytic plaque production than did middle-aged or young adult mice of the same genotype. The average plaque counts obtained with old (C57B1/ 10 X B10.LP)F1 male mice 4 to 5 times higher than those obtained with comparable younger mice. This evidence supports earlier suggestions of a meaningful association between autoimmunity and aging. We acknowledge the expert technical assistance of William Pinker ton and Beth Teviotdale.

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