Restoration of brainmyo-inositol levels in rats increases latency to lithium-pilocarpine seizures

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Abstract
Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed bymyo-inositol, rats were pretreated with intracerebroventricular (ICV) injections ofmyo-inositol, artificial CSF orl-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20–24 h prior to the subcutaneous injection of pilocarpine 20 or 30 mg/kg. In both experiments,myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score.myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of corticalmyo-inositol in rats injected withmyo-inositol were approximately double those of the CSF andl-chiro-inositol groups.